In a landmark longevity study, scientists at the biopharmaceutical company CCM Biosciences have discovered enzyme activators that restore a “previously undruggable” mitochondrial regulator of cellular energy production to youthful activity levels. 

These enzyme-stimulating compounds show promise for cellular rejuvenation and treating age-related diseases, the company highlights. However, their development has been challenging due to reliance on allosteric modulation — a mechanism feasible in less than 10% of proteins.

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