Healthy aging impact: New study reveals excessive nutrient signaling limits longevity

14 Jun 2024 — Researchers at the Spanish National Cancer Research Center (CNIO) discovered that when cells are signaled to have excess nutrients independent from increased nutrient intake, it speeds up aging. This leads to malfunction and inflammation of critical organs, including the pancreas, liver and kidneys. The research team spotlights that intervening in this inflammation may relieve symptoms and increase survival. 

In the animal model study, the CNIO team found that when the mTOR protein complex (a central regulator of cell metabolism and physiology) is slightly increased, aging starts earlier and can shorten animals’ lifetimes by up to 30%.