Psychedelics for depression: Clinical trial finds “rapid and robust response” with psilocybin

06 Sep 2023 — Psilocybin treatment was found to clinically and significantly reduce depressive symptoms and functional disability without serious adverse events in a new randomized, placebo-controlled clinical trial. Study participants received one dose of the psychedelic and psychological support before, during and after dosing. 

“The psilocybin produced a rapid, robust and sustained antidepressant response,” says lead author Charles Raison, director of clinical and translational research for the Usona Institute, which explores consciousness-expanding medicines to address mental health conditions, in a recent JAMA author interview.